The No. 12 Ohio State Buckeyes will host the No. 23 Oregon Ducks in a highly anticipated Big Ten matchup on Saturday, November 7, 2026. The game, scheduled for 3:30 p.m. ET at Ohio Stadium in Columbus, will be broadcast on CBS and Paramount+. Both programs enter the contest with recent momentum shifts and significant injuries to their starting quarterbacks.
Ohio State, currently holding a 6-2 record with a 4-1 conference mark, is looking to bounce back after its five-game winning streak was snapped by unranked USC. The Trojans defeated the Buckeyes 30-18 on Saturday, marking the first loss for Columbus this season. Oregon, which sits at 5-3 overall and 3-2 in the Big Ten, is coming off a 34-26 upset victory over then-No. 20 Northwestern in Week 9.
A major factor in this week's matchup is the absence of both teams' starting signal callers. Ohio State will be without Julian Sayin due to an arm injury, while Oregon is dealing with a concussion that sidelines Dante Moore. Despite these setbacks, both backup quarterbacks have demonstrated the ability to keep their offenses productive in recent weeks.
Oregon's substitute, Dylan Raiola, threw for 336 yards and three touchdowns in his previous appearance. Meanwhile, Ohio State's true freshman Luke Fahey delivered a strong performance in a hostile environment at USC, recording 260 passing yards, one touchdown, and no turnovers. Projections suggest that these two backups could combine for over 500 passing yards in the upcoming contest.
The historical context between these two teams favors a high-scoring affair. Ohio State leads the all-time series 3-2, but the last four meetings between the Buckeyes and Ducks have all featured more than 60 combined points. Furthermore, the total points have gone over the limit in all four of Ohio State's home games in 2026, as well as in two of Oregon's three road contests this season.
Betting markets have priced Ohio State as 7.5-point favorites for the Saturday showdown. The over/under line for total points is set at 45.5. SportsLine, which uses a projection model that simulates every game 10,000 times, predicts that the over will hit in 56% of these simulations. The model also notes that the over has a 5-1 record in Oregon's last six games as an underdog.
According to the SportsLine projection, one side of the spread is expected to cover in more than 60% of the simulated scenarios. The model entered Week 10 with a season record of 80-77 on its top-rated college football picks. Fans and bettors are advised to review these projections before placing wagers on the Saturday afternoon game.
The contest represents a critical test for both teams as they navigate the latter part of the regular season. With both offenses relying on new starters at quarterback, the outcome could hinge on how well each team manages the transition and maintains its scoring efficiency. The high projected point total reflects the confidence in both offensive units despite the personnel changes.
