A notable Big Ten contest highlights the Week 10 college football slate, as the No. 12 Ohio State Buckeyes welcome the No. 23 Oregon Ducks to Ohio Stadium in Columbus, Ohio. Kickoff is set for 3:30 p.m. ET, with the game airing on CBS and streaming on Paramount+.
Ohio State enters at 6-2 overall and 4-1 in conference play, but momentum is not on its side. The Buckeyes had a five-game winning streak snapped last Saturday in a 30-18 loss to an unranked USC team. Oregon, sitting at 5-3 and 3-2 in the Big Ten, arrives with confidence after knocking off then-No. 20 Northwestern 34-26 in Week 9.
Both offenses will be led by backups, as each team has lost its starting quarterback. Julian Sayin is out for Ohio State with an arm injury, while Oregon will be without Dante Moore, who is dealing with a concussion. The Buckeyes could also be short-handed at receiver, with Brandon Inniss listed as doubtful.
Oddsmakers still like the home team. Ohio State is a 7.5-point favorite in the latest Oregon vs. Ohio State odds, and the over/under for total points is set at 45.5.
The SportsLine Projection Model, which simulates every FBS game 10,000 times, is leaning toward the Over on the total. The model sees the Over cashing in 56% of its simulations for this matchup.
History and recent trends support that call. Each of the last four meetings between these programs has been a high-scoring affair, with all four surpassing 60 combined points. The total has gone Over in all four of Ohio State's home games in 2026, as well as in two of Oregon's three road games. The Over also holds a 5-1 record across the Ducks' last six games as an underdog.
The absence of the starting quarterbacks did not slow either offense a week ago. Oregon's Dylan Raiola threw for 336 yards and three touchdowns, while Ohio State true freshman Luke Fahey posted 260 yards, one touchdown and zero turnovers in a hostile environment at USC. The two backups are projected to combine for more than 500 passing yards on Saturday.
As for the spread, the model indicates that one side hits in more than 60% of simulations, with that pick available exclusively at SportsLine. The model entered Week 10 with an 80-77 record on all of its top-rated college football picks at betting sites this season.
